Quick Answer: How Can You Differentiate Between Iron Deficiency Anemia And Thalassemia Depending On CBC?

Can you take iron if you have Thalassemia?

If you have thalassemia trait, your physician may prescribe iron supplements because your red blood cells are smaller than is typical.

Unless you also have iron deficiency in addition to thalassemia, this is not needed and should be avoided..

How do you check for iron deficiency?

A patient’s total body iron deficit can be calculated using the Ganzoni formula (total iron dose = [actual body weight × (15-actual Hb)] × 2.4 + iron stores) [32]. Because many view this formula as inconvenient, it is not consistently used in clinical practice [37].

What is the one best test to evaluate for iron deficiency?

Measurement of the serum ferritin level is the most accurate test to diagnose iron deficiency anemia. All pregnant women should be screened for iron deficiency anemia. All adult men and postmenopausal women with iron deficiency anemia should be screened for gastrointestinal malignancy.

What are the 3 stages of iron deficiency?

There are many facets of iron deficiency which include: iron loss, iron intake, iron absorption, and physiological demand and if the iron is depleted at one of these sources it leads to IDA. There are three stages to iron deficiency: pre-latent, latent, and IDA.

It has long been considered that iron deficiency does not exist in thalassemia syndromes, including thalassemia major as well as trait. However, studies have shown the occurrence of iron deficiency in patients with beta thalassemia trait (BTT).

Why can’t thalassemia take iron?

People with thalassaemia may be advised to avoid iron supplements because they are at risk of iron overload. Carriers of the thalassaemia gene may be asymptomatic but pregnancy can precipitate anaemia and there is a chance that this may be inappropriately treated with iron replacement.

Does thalassemia affect your menstrual cycle?

Puberty may be delayed or progress abnormally in teenagers with thalassemia, due to iron build up impairing the function of the pituitary gland. This may lead to complications such as: Absence of menstruation, known as amenorrhea.

How does thalassemia minor affect the body?

Thalassemia can quickly lead to anemia. This condition is marked by a lack of oxygen being transported to tissues and organs. Since red blood cells are responsible for delivering oxygen, a reduced number of these cells means you don’t have enough oxygen in the body either. Your anemia may be mild to severe.

What does a CBC look like with thalassemia?

People who have alpha thalassemia trait have red blood cells (RBCs) that are smaller (microcytic) and paler (hypochromic) than normal, have a decreased MCV (mean corpuscular volume, a measurement of the average size of a single RBC), and have a mild chronic anemia.

What are the symptoms of thalassemia minor?

Thalassemia signs and symptoms can include:Fatigue.Weakness.Pale or yellowish skin.Facial bone deformities.Slow growth.Abdominal swelling.Dark urine.

Can thalassemia be misdiagnosed?

It is commonly misdiagnosed and treated for iron deficiency. If unusually high plasma iron or serum ferritin is encountered in beta thalassemia trait one should rule out coexisting hemochromatosis or iron supplementation. Women carriers can develop moderately severe anemia during pregnancy.

How do you rule out thalassemia?

Diagnosis. Doctors diagnose thalassemias using blood tests, including a complete blood count (CBC) and special hemoglobin tests. A CBC measures the amount of hemoglobin and the different kinds of blood cells, such as red blood cells, in a sample of blood.

What is thalassemia syndrome?

Español (Spanish) Thalassemia is an inherited (i.e., passed from parents to children through genes) blood disorder caused when the body doesn’t make enough of a protein called hemoglobin, an important part of red blood cells.

How can you tell the difference between iron deficiency and thalassemia?

The first difference is in the red blood cell count (labeled RBC). In iron deficiency, this value is low because the bone marrow is unable to manufacture red blood cells. In thalassemia trait, RBC is normal to elevated. 2 A normal ferritin level can rule out iron deficiency.

When should a CBC be repeated after starting iron?

Once treatment with iron is started, it is important to repeat a CBC and iron panel in 2-3 months to assess response to treatment. Individuals with chronic nose or GI bleeding who tolerate oral iron should continue to take this long term.